GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs10935120 | 1 | rs4572812 | chr3:134291177 | ANAPC13 | chr3:134196547-134204865:- | -0.39 | -12.33 | 1.64E-30 | Height |
| THCA | cis | rs10935120 | 1 | rs4572812 | chr3:134291177 | CEP63 | chr3:134204575-134293852:+ | -0.31 | -6.56 | 1.43E-10 | Height |
| THCA | cis | rs9902453 | 1 | rs4575590 | chr17:28361969 | ANKRD13B | chr17:27916801-27941778:+ | -0.36 | -8.85 | 1.7E-17 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4575590 | chr17:28361969 | CORO6 | chr17:27941774-27948441:- | -0.51 | -11.7 | 5.47E-28 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4575590 | chr17:28361969 | EFCAB5 | chr17:28256874-28435469:+ | -0.6 | -11.3 | 2.02E-26 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4575590 | chr17:28361969 | GIT1 | chr17:27900487-27916610:- | -0.29 | -6.8 | 3.15E-11 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4575590 | chr17:28361969 | LRRC37B2 | chr17:28903483-28992715:+ | -0.18 | -3.84 | 0.000141 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4575590 | chr17:28361969 | SSH2 | chr17:27952965-28257018:- | -0.34 | -7.64 | 1.18E-13 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4575590 | chr17:28361969 | TP53I13 | chr17:27895739-27900174:+ | -0.2 | -5.3 | 1.81E-7 | Coffee consumption (cups per day) |
| THCA | cis | rs7665090 | 1 | rs4579121 | chr4:103558169 | CISD2 | chr4:103790135-103809913:+ | -0.16 | -3.62 | 0.000321 | Primary biliary cirrhosis |
| THCA | cis | rs7665090 | 1 | rs4579121 | chr4:103558169 | NFKB1 | chr4:103422486-103538458:+ | 0.15 | 4.2 | 3.16E-5 | Primary biliary cirrhosis |
| THCA | cis | rs7714584 | 1 | rs4579248 | chr5:150268151 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.7 | 2.1E-8 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs4579248 | chr5:150268151 | ZNF300 | chr5:150273964-150284391:- | 0.16 | 3.35 | 0.000867 | Crohn's disease |
| THCA | cis | rs6499255 | 1 | rs4580150 | chr16:69814953 | COG4 | chr16:70514473-70557457:- | -0.19 | -3.95 | 9.15E-5 | IgE levels |
| THCA | cis | rs11734488 | 1 | rs4580699 | chr4:139120444 | SLC7A11 | chr4:139085248-139163503:- | 0.22 | 4.47 | 9.97E-6 | Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect) |